344301

sFRP Inhibitor II

The sFRP Inhibitor II, also referenced under CAS 302804-57-5, controls the biological activity of sFRP. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

• 别名: sFRP Inhibitor II, Wnt Pathway Activator V, 2-(2-(2-Imino-4-oxo-thiazolidin-5-yl)-acetylamino)-4,5-dimethyl-thiophene-3-carboxylic acid ethyl ester, Secreted Frizzled Related Protein-1 Inhibitor II
• 经验公式（希尔记法）: C₁₄H₁₇N₃O₄S₂
• CAS号: 302804-57-5
• 分子量: 355.43
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: off-white
• 溶解性: DMSO: 100 mg/mL
• 运输: ambient
• 储存温度: −20°C

说明

一般描述

A cell-permeable iminooxothiazolidine compound that is shown to counteract the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and restore cellular response to Wnt-3 stimulation (by a 2.3-fold enhancement at 15 µM) in U2OS-based reporter assays. Also reported to increase total bone area and the number of osteoblasts (by ~20% and ~45%, respectively) in a murine ex vivo calvarial bone formation assay.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Shi, M., et al. 2009. Bioorg. Med. Chem. Lett.19, 6337.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable