344280

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

• 别名: Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem, FST, Phosphotrienin
• 经验公式（希尔记法）: C₁₉H₂₆NaO₉P
• CAS号: 87860-39-7
• 分子量: 452.37
• MDL编号: MFCD09971059
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: colorless
• 溶解性: ethanol: 10 mg/mL; methanol: 10 mg/mL; water: 50 mg/mL
• 运输: ambient
• 储存温度: −20°C

说明

一般描述

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G₂/M phase of the cell cycle in a dose-dependent manner.

Antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC₅₀ = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

生化/生理作用

Cell permeable: no

Primary Target
PP2a

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Cheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable