一般說明
AXIS Axon Isolation Devices, 150 μm long channels, 10 devices
Kit belongs to the family of type III receptor tyrosine kinases. It mediates the cellular response to stem cell factor and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells and reproductive stem cells. The activation of Kit is tightly regulated and uncontrolled Kit activity contributes to the growth of diverse human tumours. Gain-of-function mutations have been described in a number of malignancies, including acute myeloid leukaemia, small cell lung cancer, gastrointestinal stromal tumours and testicular cancer. Negative regulation of Kit signalling has been shown to occur mainly through ubiquitin-mediated internalization and degradation of the receptor.
應用
Recombinant human Kit, amino acids 544-end. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
Ubiquitination Cascade Comoponent:Substrate
外觀
Format: Purified using glutathione sepharose.
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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