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Merck
所有图片(1)

文件

20-107

Sigma-Aldrich

过氧亚硝酸盐

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About This Item

分類程式碼代碼:
41116012
eCl@ss:
32160405
NACRES:
NA.41

形狀

liquid

品質等級

製造商/商標名

Upstate®

技術

western blot: suitable

運輸包裝

dry ice

一般說明

过氧亚硝酸盐(ONOO−)是一种强效氧化剂,由一氧化氮和超氧化物碰撞形成。

應用

过氧亚硝酸盐可用于诱导鼠大脑中的周细胞收缩。在免疫组织化学研究中,它已用于制备硝化蛋白标准品阳性对照。

生化/生理作用

过氧亚硝酸盐(ONOO−)具有杀菌活性。它促进细胞死亡,并有助于信号转导过程、线粒体功能和细胞凋亡途径。过氧亚硝酸盐的形成与各种疾病(包括血管疾病、缺血-再灌注损伤、循环休克、炎症、疼痛和神经退行性病变)的发展有关。

品質

通过处理未刺激的A431细胞进行常规评估。

外觀

0.3M NaOH

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Corrosion

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

儲存類別代碼

8B - Non-combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Beckman, J S and Crow, J P
Biochemical Society Transactions, 21, 330-334 (1993)
L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
A Patel et al.
Journal of endocrinological investigation, 25(8), 675-683 (2002-09-21)
Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested
Hongjun Jin et al.
Current protocols in toxicology, Chapter 17, Unit 17-Unit 17 (2012-04-19)
Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are derived as a result of inflammation and oxidative stress and can result in protein modifications. As such, these protein modifications are used as biomarkers for inflammation and oxidative stress. In

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