200485

Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem

• 别名: Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem, (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
• 经验公式（希尔记法）: C₁₇H₂₆N₂O₄
• CAS号: 65322-89-6
• 分子量: 322.40
• 分類程式碼代碼: 12352200

属性

• 化驗: ≥97% (TLC)
• 品質等級: 100
• 形狀: semisolid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: yellowish
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

说明

一般說明

This product has been discontinued.

A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.

A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC₅₀ = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC₅₀ = 400.1 nM). Also reported to augment Fas- (IC₅₀ = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.

生化／生理作用

Cell permeable: yes

Primary Target
Neutral amino pepsidase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 31.6 nM against neutral amino pepsidase

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

準備報告

Unstable in aqueous solution; dilute just prior to use.

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他說明

Sekine, K., et al. 2001. Int. J. Cancer94, 485.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10-13 - German Storage Class 10 to 13