推荐产品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
mouse, human
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
phosphorylation (pTyr1158/pTyr1162/pTyr1163)
基因資訊
human ... INSR(3643)
特異性
Human and mouse phospho-Insulin Receptor (IR) Tyrosine 1158/1162/1163 and Insulin-like Growth Factor 1 Receptor (IGF1R) Tyr 1131/1135/1136. Rat reactivity is expected based on 100% sequence homology.
Predicted to cross-react with rat based on 100% sequence homology, but have not been tested.
免疫原
Peptide corresponding to the amino acid region encompassing the human, mouse, and rat phospho-Insulin Receptor (IR) Tyrosine 1158, 1162, and 1163 and Insulin-like Growth Factor 1 Receptor (IGF1R) Tyr 1131, 1135, and 1136.
應用
Anti-phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) Antibody detects level of phospho-IR/IGF1R (Tyr1158/Tyr1162/Tyr1163) & has been published & validated for use in WB.
Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-IR (Tyr1158/Tyr1162/Tyr1163) in RIPA lysate of untreated and insulin treated CHO cells transfected with IR.
Research Category
Signaling
Signaling
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
品質
Routinely evaluated by immunoblot.
標靶描述
155 kDa
外觀
Affinity purified
100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
儲存和穩定性
Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Aaron Cooper et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(1), 56-66 (2010-11-05)
Ewing sarcoma family tumors (ESFT) are aggressive tumors of putative stem cell origin for which prognostic biomarkers and novel treatments are needed. In several human cancers, high expression of the polycomb protein BMI-1 is associated with poor outcome. We have
R Chugh et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 26(7), 1459-1464 (2015-04-11)
Insulin-like growth factor receptor (IGF-1R) has been studied as an oncologic target in soft tissue sarcoma (STS), but its role in sarcoma biology is unclear. Anti-IGF-1R antibody cixutumumab demonstrated acceptable toxicity but limited activity as a single agent in STS.
Marina C Muñoz et al.
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The I kappaB kinase-beta (IKK-beta)/nuclear factor-kappaB signaling pathway has been suggested to link inflammation with obesity and insulin resistance. In addition, angiotensin (Ang) II is able to induce insulin resistance and an inflammatory state through Ang II receptor type 1
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Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-established anti-insulin effects of GH, cardiac insulin resistance may play a role in the cardiopathology observed in acromegalic
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Mutations in BSCL2 gene underlie human type 2 Berardinelli-Seip Congenital Lipodystrophy (BSCL2) disease. Global Bscl2-/- mice recapitulate human BSCL2 lipodystrophy and develop insulin resistance and hypertrophic cardiomyopathy. The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are
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