07-2178

Anti-Abl interactor 1 Antibody

from rabbit, purified by affinity chromatography

• 别名: Abl interactor 1, Abelson interactor 1, Abi-1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Eps8-binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain-binding protein 1, e3B1
• UNSPSC代码: 12352203
• eCl@ss: 32160702

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 纯化方式: affinity chromatography
• 种属反应性: human, mouse
• 种属反应性（根据同源性预测）: rat (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 技术: western blot: suitable
• NCBI登记号: NP_005461
• UniProt登记号: Q8IZP0
• 运输: wet ice
• 靶向翻译后修饰: unmodified
• 基因信息: bovine ... Abi1(540815) ; human ... ABI1(10006) ; mouse ... Abi1(11308) ; rat ... Abi1(79249)

说明

一般描述

Abl interactor 1 (Abelson interactor 1) is a member of the family of Abl-interactors and is highly expressed in the brain. Abl interactor 1 is involved in the signaling of ABL1 and ABL2 nonreceptor tyrosine kinases, and the EGF-receptor. The Abl interactor 1 protein contains SH3 domains, and may function as an adaptor protein; It forms a trimeric complex with EPS8 and SOS1 in the transduction of signals from Ras to Rac. Previous studies have suggested that Abl interactor 1 via the Ras and Rac pathways may regulate cell proliferation, cell adhesion, and actin remodeling. Abl interactor 1 is also investigated for its role in tumor suppression.

免疫原

KLH-conjugated linear peptide corresponding to human Abl interactor 1.

应用

Detect Abl interactor 1 using this Anti-Abl interactor 1 Antibody validated for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Abl interactor 1 on 10 µg of Jurkat cell lysate.

目标描述

~60 kDa observed. Uniprot describes many isoforms between 43-55 kDa that can be highly phosphorylated.

外形

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Jurkat cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable