生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human, mouse
技術
immunofluorescence: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... EIF4G1(1981)
一般說明
eIF4F is a translation initiation factor containing three subunits: eIF4A, eIF4E, and eIF4G. This complex is a key component in promoting ribosomal binding to the mRNA. eIF4G interacts with both eIF4A and eIF4E though its carboxy and amino terminal domains, respectively. eIF4E binds to the cap structure of the mRNA, while the ATP-dependent RNA helicase eIF4A unwinds the secondary structure of the 5’ UTR. eIF4G plays a critical role in coordinating the assembly of the eukaryotic initiation factors. It acts as a bridge to bind the cap-bound eIF4E, eIF4AI&II, the eIF3 complex, PABP1, and the kinase Mnk1 (Lejeune, F., et al., 2004) in a large eukaryotic initiation factor complex
特異性
Not tested on other species.
This antibody detects eIF4G at its N-terminal region.
免疫原
Epitope: N-terminus
Synthetic peptide corresponding to N-terminal region of human eIF4G.
應用
Anti-eIF4G Antibody is an antibody against eIF4G for use in WB & IF.
Research Category
Signaling
Signaling
Research Sub Category
RNA Binding Protein (RBP)
Insulin/Energy Signaling
RNA Binding Protein (RBP)
Insulin/Energy Signaling
品質
Evaluated by western blot on HeLa cytoplasmic extract.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
標靶描述
220 kDa
外觀
Rabbit polyclonal serum with 0.05% NaN3.
儲存和穩定性
Stable for 1 year at -20ºC from date of receipt.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
Huanru Wang et al.
International journal of molecular sciences, 20(19) (2019-10-03)
Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates inflammation and immunity. Knowledge of its regulatory mechanisms is very limited. Here, we showed that enterovirus 71 (EV71) infection induced the phosphorylation of STAT3 and the
Daniel A Columbus et al.
American journal of physiology. Endocrinology and metabolism, 309(6), E601-E610 (2015-09-17)
Most low-birth weight infants experience extrauterine growth failure due to reduced nutrient intake as a result of feeding intolerance. The objective of this study was to determine whether prolonged enteral leucine supplementation improves lean growth in neonatal pigs fed a
Marko Rudar et al.
American journal of physiology. Endocrinology and metabolism, 321(6), E737-E752 (2021-11-02)
Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective
Marko Rudar et al.
American journal of physiology. Endocrinology and metabolism, 320(3), E551-E565 (2021-01-12)
Extrauterine growth restriction in premature infants is largely attributed to reduced lean mass accretion and is associated with long-term morbidities. Previously, we demonstrated that prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in skeletal muscle of
Anat Bahat et al.
EMBO molecular medicine, 16(3), 523-546 (2024-02-20)
Huntington's disease (HD) is an incurable inherited disorder caused by a repeated expansion of glutamines in the huntingtin gene (Htt). The mutant protein causes neuronal degeneration leading to severe motor and psychological symptoms. Selective downregulation of the mutant Htt gene
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