推荐产品
等級
certified reference material
品質等級
形狀
solid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 10 mg
製造商／商標名
Cerilliant®
藥物控制
regulated under CDSA - not available from Sigma-Aldrich Canada
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
forensics and toxicology
形式
neat
儲存溫度
−20°C
一般說明
A Certified Reference Material of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.
應用
- DNA precipitation: This compound is vital for DNA precipitation protocols where it facilitates the aggregation of DNA fragments by reducing their solubility in water. This application is essential for genetic engineering and molecular biology experiments (Park et al., 2023).
- Cell culture: In cell culture, ammonium sulfate is used to control the osmotic pressure of culture media, which is crucial for maintaining the health and viability of cultured cells, thus supporting tissue engineering and cellular research (Qin et al., 2024).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - STOT SE 3
標靶器官
Central nervous system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
M Rosa Boleda et al.
Chemosphere, 84(11), 1601-1607 (2011-06-15)
A total of seventy samples of drinking water were tested for non-controlled and illicit drugs. Of these, 43 were from Spanish cities, 15 from seven other European countries, three from Japan and nine from seven different Latin American countries. The
Ana de Castro et al.
Therapeutic drug monitoring, 33(4), 443-452 (2011-07-12)
The purpose was to explore methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) umbilical cord disposition, correlate with maternal methadone dose and neonatal outcomes, and evaluate the window of drug detection in umbilical cord of in utero illicit drug exposure. Subjects comprised 19 opioid-dependent
Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients.
Edijs Leimanis et al.
Journal of analytical toxicology, 36(4), 239-249 (2012-04-19)
Methadone is used to treat moderate to severe pain in patients not responsive to non-narcotic analgesics and for maintenance treatment of opioid addiction. Methadone is primarily metabolized by N-demethylation to an inactive metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene (EDDP) by CYP3A4 and CYP2B6. Establishing
Wenjie Jessie Lu et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(8), 1308-1313 (2010-04-23)
The peripheral conversion of testosterone to estradiol by aromatase is the primary source of endogenous estrogen in postmenopausal women. Studies indicating that placental aromatase is able to metabolize methadone to its primary metabolite, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidin (EDDP), led us to
Matthias Gosselin et al.
Forensic science international, 209(1-3), 154-159 (2011-02-16)
This paper describes a sensitive UPLC-MS/MS method for quantification of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in single empty puparial case of Lucilia sericata. Larvae were reared on substrates spiked with different concentrations of methadone (0-4 μg/g). Methadone was quantified in puparia
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