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Merck

870865P

Avanti

BMP22

Avanti Research - A Croda Brand, powder

别名:

4-pentadecylbenzylphosphonic acid

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About This Item

经验公式(希尔记法):
C22H39O3P
分子量:
382.52
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (870865P-1mg)
pkg of 1 × 5 mg (870865P-5mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

bioactive lipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

InChI 密鑰

XWVBRTAQHMKHCE-UHFFFAOYSA-N

一般說明

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

生化/生理作用

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

包裝

5ML Glass Amber Screw Cap Vial (870865P-1MG)
5ML Glass Amber Screw Cap Vial (870865P-5MG)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss
Flammier S, et al.
Arthritis and Rheumatism (2019)
Bis (monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Anderson DMG, et al.
Scientific Reports, 7(1), 17352-17352 (2017)
Transacylase formation of bis (monoacylglycerol) phosphate
Heravi J and Waite M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1437(3), 277-286 (1999)
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh M, et al.
Biochemical Society Transactions, 40(1), 31-36 (2012)

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