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840875C

Avanti

二油酰磷脂酸(18:1 PA)

Avanti Research™ - A Croda Brand

别名:

1,2-二-（9Z-十八烯酰）-sn-甘油-3-磷酸（钠盐）；DOPA；PA (18:1 (9Z)/18:1 (9Z))

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About This Item

经验公式（希尔记法）:
C39H72O8PNa
CAS号:
108392-02-5
分子量:
722.95
MDL编号:
MFCD00674303
UNSPSC代码:
51191904
NACRES:
NA.25

描述

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt), chloroform solution

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (840875C-25mg)
pkg of 2 × 20 mL (840875C-1g)
pkg of 2 × 4 mL (840875C-200mg)
pkg of 5 × 4 mL (840875C-500mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (840875C-25mg)
25 mg/mL (840875C-1g)
25 mg/mL (840875C-200mg)
25 mg/mL (840875C-500mg)

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na].[P](=O)(OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC)(O)O

InChI

1S/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17-,20-18-;/t37-;/m1./s1

InChI key

KHDHADSEKGCPKW-ZBFGHDQJSA-N

一般描述

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）是以磷脂酸基团为骨架的修饰脂质的钠盐。

应用

二油酰磷脂酸（18:1 PA或1,2-二油酰-sn-甘油-3-磷酸钠盐）已用于：
  • 作为磷脂酸(PA)薄层色谱(TLC)分析的合成标准品，在碘染色后确定磷脂酸位置
  • 作为脂质标准品，用于优化液相色谱−质谱 (LC-MS)分析条件
  • 作为磷脂放射性标记分析的脂质标准品

生化/生理作用

磷脂酸（PA）起脂质信使作用。它在雷帕霉素（mTOR）信号转导的哺乳动物靶标中起关键作用。

包装

30 mL带螺旋盖的琥珀色窄口玻璃瓶(840875C-1g)
5 mL透明玻璃密封安瓿(840875C-200mg)
5 mL透明玻璃密封安瓿(840875C-25mg)
5 mL透明玻璃密封安瓿(840875C-500mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xinhui Sun et al.
Cell cycle (Georgetown, Tex.), 14(5), 721-731 (2015-01-16)
It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout the reproductive life. Intra-oocyte PI3K/mTOR pathways have been indicated to play a central role on the activation
Shutao Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 174, 137-142 (2013-11-28)
The poor solubility of cisplatin (CDDP) often presents a major obstacle in the formulation of CDDP in nanoparticles (NPs) by traditional methods. We have developed a novel method for synthesizing CDDP NPs taking advantage of its poor solubility. By mixing
Shireesha Sankella et al.
The Journal of biological chemistry, 289(8), 4762-4777 (2014-01-16)
In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). Liver lysophosphatidic acid and PA levels were increased ∼2- and
Kathleen Frondorf et al.
The Journal of biological chemistry, 285(21), 15837-15847 (2010-03-23)
Phosphatidic acid (PA) is a pleiotropic lipid second messenger in mammalian cells. We report here that extracellular PA acts as a leukocyte chemoattractant, as membrane-soluble dioleoyl-PA (DOPA) elicits actin polymerization and chemotaxis of human neutrophils and differentiated proleukemic HL-60 cells.
Taylor E Miller et al.
Biology open, 6(2), 176-186 (2016-12-25)
The removal of mRNA transcript poly(A) tails by 3'→5' exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological roles and regulation for PARN is
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