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Merck
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文件

791275P

Avanti

18:0 PE-DTPA (Gd)

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder

别名:

1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt); DSPE-DTPA (Gd)

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About This Item

经验公式（希尔记法）:
C55H106GdN6O17P
CAS号:
2260795-19-3
分子量:
1311.68
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 5 mg (791275P-5mg)

製造商／商標名

Avanti Research™ - A Croda Brand 791275P

運輸包裝

dry ice

儲存溫度

−20°C

相关类别

一般說明

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.

應用

18:0 PE-DTPA (Gd) has been used:
  • as a component of Gadolinium-liposome preparation
  • in the nanodics preparation for nuclear magnetic resonance (NMR) studies
  • in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
  • as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies

生化／生理作用

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.

包裝

5 mL Amber Glass Screw Cap Vial (791275P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Fibrin-targeting, peptide amphiphile micelles as contrast agents for molecular MRI
Chung EJ, et al.
journal of Cell Science & Therapy, 5(5), 1-1 (2014)
Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
Vavra J, et al.
Advances in Functional Materials, 28(45), 1803406-1803406 (2018)
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored
Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
Pavlína Šimečková et al.
Scientific reports, 10(1), 4780-4780 (2020-03-18)
Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and

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