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描述
cholest-5-en-3β,7β-diol
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 10 mg (700035P-10mg)
pkg of 1 × 25 mg (700035P-25mg)
pkg of 1 × 5 mg (700035P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
InChI
1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20?,21-,22+,23+,24+,25+,26+,27-/m1/s1
InChI 密鑰
OYXZMSRRJOYLLO-ISPKDCJXSA-N
一般說明
7β-羟基胆固醇（7β-OHC）是一种氧化甾醇，由低密度脂蛋白（LDL）氧化合成。它主要在肝脏分解代谢为胆汁酸。
應用
7β-羟基胆固醇已被用于：
- 用作液相色谱-质谱（LC-MS）中的内部氧甾醇标准品，用于在抑制剂AY9944治疗后对神经球中与胆固醇生物合成相关的甾醇进行定量
- 重组高密度脂蛋白（HDL），用于胰岛素瘤细胞系INS1e中的抗凋亡研究
- 用作超高效液相色谱（UHPLC）与高分辨率四极杆飞行时间质谱（Q-TOF）联用的胆固醇氧化产物标准品
生化／生理作用
7β-羟基胆固醇（7β-OHC）通过基于半胱天冬酶8的线粒体途径促进细胞凋亡。它还通过产生活性氧（ROS）阻碍癌细胞的存活。多发性硬化症和阿尔茨海默′病（AD）患者的脑脊液中7β-OHC水平升高。7β-OHC还促进氧化凋亡和脱髓鞘。它激活丝裂原活化蛋白激酶并调节细胞内Ca2+稳态，可能有助于高尔基体和内质网膜的解体。
包裝
5 mL琥珀色玻璃螺旋盖小瓶(700035P-10mg)
5 mL琥珀色玻璃螺旋盖小瓶(700035P-25mg)
5 mL琥珀色玻璃螺旋盖小瓶（700035P-5mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Amira Zarrouk et al.
Biochimie, 153, 210-219 (2018-07-14)
Some oxysterols resulting either from enzymatic oxidation or autoxidation of cholesterol are associated with age-related diseases including neurodegenerative diseases. Among these oxysterols, 7β-hydroxycholesterol (7β-OHC) is often found at increased levels in patients. It is therefore important to identify molecules or
M P Ares et al.
Atherosclerosis, 153(1), 23-35 (2000-11-04)
In the present study, we characterize the early cytotoxic effects of 7beta-hydroxycholesterol, a major cytotoxin in oxidized LDL, in human aortic smooth muscle cells. Within a few minutes after addition, 7beta-hydroxycholesterol induced Ca(2+) oscillations with a frequency of approximately 0.3-0.4
Kyoung Ah Kang et al.
Biological & pharmaceutical bulletin, 28(8), 1377-1380 (2005-08-05)
The cytotoxic activity of 7beta-hydroxycholesterol (7beta-OHC) was evaluated on human NCI-H460 lung cancer cells. 7beta-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7beta-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G(1) hypodiploid (apoptotic)
Changguang Wang et al.
International journal of pharmaceutics, 569, 118576-118576 (2019-07-31)
Cholesterol is one of the major structural constituents in a liposomal bilayer. Cholesterol is susceptible to various reactions in the presence of oxygen, heat, light, certain metals, and radicals during manufacturing or storage, which may cause to generate cholesterol oxidation
Sinead Lordan et al.
International journal of toxicology, 27(3), 279-285 (2008-06-24)
The induction of apoptosis in cells of the arterial wall is a critical event in the development of atheroma. 7beta-Hydroxycholesterol (7beta-OH) and cholesterol-5beta,6beta-epoxide (beta-epoxide) are components of oxLDL and have previously been shown to be potent inducers of apoptosis. However
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