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Merck

N1909

Sigma-Aldrich

1-萘甲酸

96%

别名:

1-萘酸

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About This Item

线性分子式:
C10H7CO2H
CAS号:
分子量:
172.18
Beilstein:
1908896
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

96%

形狀

powder

bp

300 °C (lit.)

mp

157-160 °C (lit.)

SMILES 字串

OC(=O)c1cccc2ccccc12

InChI

1S/C11H8O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H,12,13)

InChI 密鑰

LNETULKMXZVUST-UHFFFAOYSA-N

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應用

1-萘甲酸可作为以下应用的反应剂:
  • 在铑催化剂存在下,与炔烃通过脱水环化反应制备萘嵌苯酮。
  • 使用Rh催化剂,与2-丁炔通过有氧的氧化环化反应制备异香豆素衍生物。
  • N,O-二甲基羟胺和三氯化磷反应制备N-甲氧基-N-甲基-1-萘甲酰胺(Weinreb酰胺)。
  • 通过Birch还原反应制备1,4-二氢-1-萘羧酸。

其他說明

残留物为 2-萘甲酸

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Qunfei Zhao et al.
Chemistry & biology, 15(7), 693-705 (2008-07-19)
Azinomycin B is a complex natural product containing densely assembled functionalities with potent antitumor activity. Cloning and sequence analysis of the azi gene cluster revealed an iterative type I polyketide synthase (PKS) gene, five nonribosomal peptide synthetases (NRPSs) genes and
Rajesh Sunasee et al.
The Journal of organic chemistry, 73(20), 8016-8020 (2008-09-26)
A method is described for converting tert-butyl benzoates or tert-butyl 1-naphthoates into derivatives having an alkyl or substituted alkyl group in a 1,4-relationship to an alkyl, aryl, alkenyl, or alkynyl group. Key steps in the sequence are (i) addition of
Mutual activation: Suzuki-Miyaura coupling through direct cleavage of the sp2 C-O bond of naphtholate.
Da-Gang Yu et al.
Angewandte Chemie (International ed. in English), 50(31), 7097-7100 (2011-06-29)
Hiromasa Uchiyama et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 43(1-2), 71-77 (2011-04-06)
Spray-dried particles (SDPs) with indomethacin (IND) and alpha-glycosyl transferase-treated stevia (Stevia-G) indicated extremely high dissolution rates and apparent solubility compared to particles of a ground mixture and a physical mixture of IND/Stevia-G. The apparent solubility of IND from SDPs was
Synthesis of perinaphthenones through rhodium-catalyzed dehydrative annulation of 1-naphthoic acids with alkynes
Fukuyama T, et al.
Organic & Biomolecular Chemistry, 16, 7583-7587 (2018)

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