902683

BocNH-PEG5-acid

• 别名: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• 经验公式（希尔记法）: C₁₇H₃₃NO₉
• CAS号: 890152-41-7
• 分子量: 395.45
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 形狀: liquid
• 反應適用性: reaction type: Pegylations; reagent type: cross-linking reagent
• 官能基: Boc; amine; carboxylic acid
• 儲存溫度: −20°C
• SMILES 字串: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

说明

應用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable