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98%
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[α]20/D −385°, c = 2 in H2O
mp
248-250 °C (lit.)
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OC(=O)[C@H]1NCC=C1
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Hyuk Sung Kwon et al.
Bioorganic & medicinal chemistry letters, 21(14), 4325-4328 (2011-06-15)
Oxygen dependent degradation of hypoxia-inducible factor (HIF)-1α is triggered with hydroxylation by proline hydroxylase domain 2 (PHD2) under normoxic conditions. Some of previously developed PHD2 inhibitors show a considerable potency against factor inhibiting HIF (FIH), the HIF asparagine hydroxylase. For
Griet Van Zeebroeck et al.
Nature chemical biology, 5(1), 45-52 (2008-12-09)
Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid analogs to identify compounds that act on Gap1
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