推荐产品
化驗
≥95.0% (HPLC)
形狀
powder
光學活性
[α]/D −74±4°, c = 1% in 0.1 M NaOH
mp
220-223 °C (lit.)
儲存溫度
−20°C
SMILES 字串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(S)ncnc23
InChI
1S/C10H12N4O4S/c15-1-4-6(16)7(17)10(18-4)14-3-13-5-8(14)11-2-12-9(5)19/h2-4,6-7,10,15-17H,1H2,(H,11,12,19)/t4-,6-,7-,10-/m1/s1
InChI 密鑰
NKGPJODWTZCHGF-KQYNXXCUSA-N
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Lennard P L Gilissen et al.
Journal of Crohn's & colitis, 6(6), 698-707 (2012-03-09)
Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN
Sumit Parmar et al.
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To adopt an individualized approach to assess cytarabine (ara-C) hematotoxicity, we studied the relationship between pharmacogenetic variability in the cytidine deaminase gene (CDA) and ara-C toxicity in native peripheral blood mononuclear cells from 100 healthy volunteers. Peripheral blood mononuclear cells
Anwar Saad Abd-Elfattah et al.
The Journal of thoracic and cardiovascular surgery, 144(1), 250-255 (2012-02-15)
To determine the role of the p-nitrobenzylthioinosine-sensitive equilibrative nucleoside transporter 1 (es-ENT1) in postmyocardial infarction reperfusion injury-mediated ventricular fibrillation and regional dysfunction. We used erythro-9 (2-hydroxy-3-nonyl)-adenine and p-nitrobenzylthioinosine to inhibit both adenosine deamination and transport in a canine model of
Daniel Pecher et al.
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Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP
Microwave-promoted "one-pot" synthesis of 4-nitrobenzylthioinosine analogues using thiourea as a sulfur precursor.
Hong-Ying Niu et al.
Chemistry, an Asian journal, 7(1), 45-49 (2011-10-18)
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