推荐产品
化驗
≥98.0% (T)
折射率
n20/D 1.431
bp
82-83 °C/11 mmHg (lit.)
mp
8-10 °C
密度
1.055 g/mL at 20 °C (lit.)
儲存溫度
2-8°C
SMILES 字串
CC(C)CC(=O)C(O)=O
InChI
1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)
InChI 密鑰
BKAJNAXTPSGJCU-UHFFFAOYSA-N
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一般說明
4-Methyl-2-oxovaleric acid, also known as α-ketoisocaproic acid (KIC), is a metabolite of leucine. It is commonly used as a building block in the synthesis of leucine and its derivatives, and it plays a role in amination reactions and asymmetric synthesis. Additionally, KIC serves as an intermediate in the formation of Strecker aldehydes.
應用
- 在人脑酮体代谢中的作用：4-甲基-2-氧戊酸参与创伤性脑损伤患者脑微透析液中酮体代谢的时间模式，说明其在大脑生化通路中的重要作用(Eiden et al., 2019)。
訊號詞
Danger
危險聲明
危險分類
Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
其他客户在看
Lisa S Chow et al.
American journal of physiology. Endocrinology and metabolism, 291(4), E729-E736 (2006-05-18)
Despite being an anabolic hormone in skeletal muscle, insulin's anticatabolic mechanism in humans remains controversial, with contradictory reports showing either stimulation of protein synthesis (PS) or inhibition of protein breakdown (PB) by insulin. Earlier measurements of muscle PS and PB
The First Highly Enantioselective Homogeneously Catalyzed Asymmetric Reductive Amination:? Synthesis of ?-N-Benzylamino Acids
Kadyrov et al.
The Journal of Organic Chemistry, 68, 4067-4070 (2003)
Intermediate role of ?-keto acids in the formation of Strecker aldehydes
Hidalgo et al.
Basic Food Chemistry, 141, 1140-1146 (2013)
Eiji Yoshihara et al.
Nature communications, 1, 127-127 (2010-12-02)
Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in
Direct Analysis of Leucine and Its Metabolites ??Hydroxy-?-methylbutyric Acid, ??Ketoisocaproic Acid, and ??HydroxyisocaproicAcid in Human Breast Milk by Liquid Chromatography?MassSpectrometry
Ehling et al.
Journal of Agricultural and Food Chemistry, 63, 7567-7573 (2015)
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