反應適用性
reaction type: Grignard Reaction
濃度
0.5 M in THF
bp
65 °C
密度
0.936 g/mL at 25 °C
儲存溫度
2-8°C
SMILES 字串
Fc1cccc([Mg]Br)c1
InChI
1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h1-2,4-5H;1H;/q;;+1/p-1
InChI 密鑰
VFPDAAQAKDGSHQ-UHFFFAOYSA-M
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應用
3-Fluorophenylmagnesium bromide is a Grignard reagent that can be used in:
- The preparation of 4-substituted quinazolines by reacting with 2-methylaminobenzonitriles.
- The synthesis of radiolabeled TrkB/C-targeting kinase inhibitor for positron emission tomography (PET) imaging applications.
- Cu-catalyzed carbometalation of substituted cyclopropenes.
法律資訊
Rieke® Metals, Inc. 产品 ®Rieke Metals, Inc. 的注册商标
Rieke is a registered trademark of Rieke Metals, Inc.
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
標靶器官
Respiratory system
安全危害
儲存類別代碼
3 - Flammable liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
1.4 °F - closed cup
閃點(°C)
-17 °C - closed cup
個人防護裝備
Faceshields, Gloves, Goggles
Facially selective and regioselective carbometalation of cyclopropenes by aryl Grignard reagents
The Journal of Organic Chemistry, 73(2), 563-568 (2008)
A kinome-wide selective radiolabeled TrkB/C inhibitor for in vitro and in vivo neuroimaging: synthesis, preclinical evaluation, and first-in-human
Journal of medicinal chemistry, 60(16), 6897-6910 (2017)
Synthesis of quinazolines via an iron-catalyzed oxidative amination of N-H ketimines
The Journal of Organic Chemistry, 83(4), 2395-2401 (2018)
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