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Merck

561665

Sigma-Aldrich

3-氟苯基溴化镁 溶液

0.5 M in THF

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About This Item

线性分子式:
FC6H4MgBr
CAS号:
分子量:
199.30
MDL號碼:
分類程式碼代碼:
12352103
PubChem物質ID:
NACRES:
NA.22

反應適用性

reaction type: Grignard Reaction

濃度

0.5 M in THF

bp

65 °C

密度

0.936 g/mL at 25 °C

儲存溫度

2-8°C

SMILES 字串

Fc1cccc([Mg]Br)c1

InChI

1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h1-2,4-5H;1H;/q;;+1/p-1

InChI 密鑰

VFPDAAQAKDGSHQ-UHFFFAOYSA-M

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應用

3-Fluorophenylmagnesium bromide is a Grignard reagent that can be used in:
  • The preparation of 4-substituted quinazolines by reacting with 2-methylaminobenzonitriles.
  • The synthesis of radiolabeled TrkB/C-targeting kinase inhibitor for positron emission tomography (PET) imaging applications.
  • Cu-catalyzed carbometalation of substituted cyclopropenes.

法律資訊

Rieke® Metals, Inc. 产品 ®Rieke Metals, Inc. 的注册商标
Rieke is a registered trademark of Rieke Metals, Inc.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

標靶器官

Respiratory system

安全危害

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

1.4 °F - closed cup

閃點(°C)

-17 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles


分析证书(COA)

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Facially selective and regioselective carbometalation of cyclopropenes by aryl Grignard reagents
Yan N, et al.
The Journal of Organic Chemistry, 73(2), 563-568 (2008)
A kinome-wide selective radiolabeled TrkB/C inhibitor for in vitro and in vivo neuroimaging: synthesis, preclinical evaluation, and first-in-human
Bernard-Gauthier V, et al.
Journal of medicinal chemistry, 60(16), 6897-6910 (2017)
Synthesis of quinazolines via an iron-catalyzed oxidative amination of N-H ketimines
Chen C, et al.
The Journal of Organic Chemistry, 83(4), 2395-2401 (2018)

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