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Merck

560871

Sigma-Aldrich

2-甲基-2-丙烷亚磺酰胺

97%, racemic

别名:

(±)--叔丁基亚磺酰胺, 1,1-二甲基乙基亚磺酰胺, 2-甲基-2-丙烷亚磺酰胺, 2-甲基丙烷-2-亚磺酰胺, 叔丁基亚磺酰胺

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About This Item

线性分子式:
(CH3)3CS(O)NH2
分子量:
121.20
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

solid

mp

97-101 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CC(C)(C)S(N)=O

InChI

1S/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3

InChI 密鑰

CESUXLKAADQNTB-UHFFFAOYSA-N

應用

合成 4-磺酰亚氨基哌啶,同时它可与苄基格氏试剂反应形成重要的制药结构单元 4-苄基-4-氨基哌啶。也可用于将亚甲基插入衍生化磺酰亚胺中,制备螺甲苯磺酰氮杂环丙烷。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Synlett, 2565-2565 (2006)
Synlett, 833-833 (2006)

商品

Ellman's sulfinamide is available in both enantiomeric and racemic forms for your research. This versatile and useful auxiliary has found extensive use both in academics and industry.

相关内容

The Ellman group has participated in the development of a variety of C-H functionalization methods. An electron rich phosphine ligand has proven to be very useful for a variety of Rh(I)-catalyzed C-C bond forming reactions applicable to heterocycle synthesis as exemplified in the recent Science paper “Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis.” Another useful ligand developed for the highly functional group compatible direct arylation of nitrogen heterocycles is described in a 2008 J. Am. Chem. Soc. paper “Rh(I)-Catalyzed Arylation of Heterocycles via C-H Bond Activation: Expanded Scope through Mechanistic Insight.” The Ellman group also developed the chiral amine reagent tert-Butanesulfinamide, which is extensively used in academics and industry for the asymmetric synthesis of amines. A comprehensive survey of tert-Butanesulfinamide methods and applications up through 2009 is provided in the 2010 Chemical Reviews article, “Synthesis and Applications of tert-Butanesulfinamide.”

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