方案
97%
mp
106-109 °C (lit.)
SMILES字符串
CCOC(=O)C1=C(C)NC(C)=C(C1CC)C(=O)OCC
一般描述
Diethyl 4-ethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is an organic building block.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
M A Correia et al.
Archives of biochemistry and biophysics, 294(2), 493-503 (1992-05-01)
Suicide inactivation of hepatic cytochrome P450 (P450) enzymes 2C11, 2C6, and 3A1/A2 by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP) in intact rats results in prosthetic heme destruction, albeit by apparently distinct mechanisms. Such heme destruction is now shown to be associated with the loss
Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins.
T R Tephly et al.
Advances in experimental medicine and biology, 197, 243-251 (1986-01-01)
E Licad-Coles et al.
Archives of biochemistry and biophysics, 338(1), 35-42 (1997-02-01)
The male-specific P450 enzyme CYP 2C11, whose expression is developmentally and hormonally regulated, is the major steroid 16alpha-hydroxylase of the untreated rat liver. The enzyme metabolizes a host of substrates, including mechanism-based inactivators, such as 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP) and spironolactone (SPL).
K Sugiyama et al.
Chemical research in toxicology, 7(5), 633-642 (1994-09-01)
The porphyrinogenic agent 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP) is known to inactivate hepatic cytochrome P450 (P450) enzymes 2C11, 2C6, and 3A1 [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-451] by different mechanisms. The inactivation of P450 2C11 and 2C6 appears to be
S M Kimmett et al.
Canadian journal of physiology and pharmacology, 72(4), 397-401 (1994-04-01)
Using progesterone 21-hydroxylase as a selective substrate for P450 2C6 in phenobarbital-treated male rats, and androstenedione and progesterone 6 beta-hydroxylases as well as erythromycin N-demethylase as selective markers for P450 3A1 in dexamethasone-treated female rats, we have shown that these
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