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Merck

376868

Sigma-Aldrich

2-(2-氨基苯基)吲哚

97%

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About This Item

经验公式(希尔记法):
C14H12N2
CAS号:
分子量:
208.26
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:

化驗

97%

mp

154-155 °C (lit.)

SMILES 字串

Nc1ccccc1-c2cc3ccccc3[nH]2

InChI

1S/C14H12N2/c15-12-7-3-2-6-11(12)14-9-10-5-1-4-8-13(10)16-14/h1-9,16H,15H2

InChI 密鑰

IAKRGXQCKYFJCB-UHFFFAOYSA-N

一般說明

2-(2-Aminophenyl)indole is an indole derivative. It has been reported as an amination reagent. 2-(2-Aminophenyl)indole undergoes condensation with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) to afford new 6-cyanoindolo[3,2-c]quinoline derivatives, having pharmacological applications.

應用

2-(2-Aminophenyl)indole may be used in the preparation of novel indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines. It may be used in the synthesis of mono and bis-indolo[1,2-c] quinazolines.
Reactant in:
  • cascade reactions of benzopyranylidenemalonates with mono- and dinucleophiles

Reactant for preparation of:
  • Mono-, bis-indolo[1,2-c]quinazolines as antimicrobial agents
  • Isocryptolepine alkaloid with antimalarial activity
  • Cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines as antitumor agents

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Synthesis of some new mono, bis-indolo [1, 2-c] quinazolines: evaluation of their antimicrobial studies.
Rohini R, et al.
Journal of the Brazilian Chemical Society, 21(5), 897-904 (2010)
Novel 6-substituted benzothiazol-2-yl indolo [1, 2-< i> c</i>] quinazolines and benzimidazo [1, 2-< i> c</i>] quinazolines.
Frere S, et al.
Tetrahedron, 59(6), 773-779 (2003)
C Lamazzi et al.
Bioorganic & medicinal chemistry letters, 10(19), 2183-2185 (2000-09-30)
Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4.5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured.
Simultaneous and Sensitive HPLC Determination of Mono-and Disaccharides, Uronic Acids, and Amino Sugars after Derivatization by Reductive Amination.
Fischer K, et al.
Acta Hydrochimica et Hydrobiologica, 31(2), 134-144 (2003)

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