372714

2,6-二甲氧基吡啶-3-羧酸

99%

• 别名: 2,6-二甲氧基烟酸
• 经验公式（希尔记法）: C₈H₉NO₄
• CAS号: 16727-43-8
• 分子量: 183.16
• MDL编号: MFCD00075582
• UNSPSC代码: 12352100
• PubChem化学物质编号: 24863158

属性

• 方案: 99%
• mp: 140-144 °C (lit.)
• SMILES字符串: COc1ccc(C(O)=O)c(OC)n1
• InChI: 1S/C8H9NO4/c1-12-6-4-3-5(8(10)11)7(9-6)13-2/h3-4H,1-2H3,(H,10,11)
• InChI key: SDJQZCSCHUIITF-UHFFFAOYSA-N

说明

一般描述

2,6-Dimethoxypyridine-3-carboxylic acid (2,6-Dimethoxynicotinic acid, DMNIH) is a piperidine derivative. It forms various organotin(IV) complexes and their antiproliferative action against pancreatic carcinoma (PANC-1), erythroleukemia (K562), and two glioblastoma multiform (U87 and LN-229) human cell lines has been evaluated.

应用

2,6-Dimethoxypyridine-3-carboxylic acid (2,6-Dimethoxynicotinic acid, DMNIH) may be used in the preparation of the following organotin(IV) complexes (DMNIH=2,6-dimethoxynicotinic acid, BZDOH=1,4-benzodioxane-6-carboxylic acid, DMFUH=2,5-dimethyl-3-furoic acid and Cy=cyclohexyl):

• [SnCy₃-(DMNI)]
• [SnCy₃(BZDO)]
• [SnCy₃(DMFU)]
• [SnPh₂-(BZDO)₂]

2,6-Dimethoxypyridine-3-carboxylic acid (2,6-dimethoxynicotinic acid, DMPH) may be used in the preparation of novel benzothiazolo naphthyridone carboxylic acid derivatives. It may be used in the preparation of following complexes, via reaction with different precursors [Ti(η⁵-C₅H₅)₂Cl₂], [Ti(η⁵-C₅H₄Me)₂Cl₂], [Ti(η⁵-C₅H₄SiMe₃)(η⁵-C₅H₅)Cl₂], [Ti(η⁵-C₅Me₅)Cl₃], SnMe₃Cl and GatBu₃:

• [Ti(η⁵-C₅H₅)₂(DMP-κO)₂]
• [Ti(η⁵-C₅H₄Me)₂(DMP-κO)₂]
• [Ti(η⁵-C₅H₄SiMe₃)(η⁵-C₅H₅)(DMP-κO)₂
• [Ti(η⁵-C₅Me₅)(DMP-κ²O,O′)₃]
• [SnMe₃(μ-DMP-κO:κO′)]_∞
• [GatBu₂(μ-DMP-κO:κO′)]₂

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Gloves