所有图片(1)
About This Item
经验公式（希尔记法）:
C19H23NO4 · 0.3CHCl3
CAS号:
分子量:
365.20
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22
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藥物控制
regulated under CDSA - not available from Sigma-Aldrich Canada
雜質
0.3 mol chloroform of crystallization
mp
180 °C (dec.) (lit.)
官能基
ether
ketone
SMILES 字串
COC1=CC2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O
InChI
1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1
InChI 密鑰
INYYVPJSBIVGPH-QHRIQVFBSA-N
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訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Liver,Kidney, Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Meng-Xiang Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 889-890, 39-43 (2012-02-22)
A sensitive and selective liquid chromatographic tandem mass spectrometric method was developed and validated for the determination of sinomenine in human plasma. Plasma samples were precipitated using methanol with metronidazole as internal standard. Separation was carried out on an Inertsil
Peng Teng et al.
European journal of medicinal chemistry, 50, 63-74 (2012-02-14)
Sinomenine (1) is clinically available for the treatment of rheumatoid arthritis (RA), however, its efficacy is quite weak. In the present study, a library of novel sinomenine-based homodimers and monomers through variable-length linkers were designed and synthesized, and their bioactivities
Yi Hong et al.
Cancer immunology, immunotherapy : CII, 62(3), 447-454 (2012-09-04)
Transferrin receptor (TfR) has been used as a target for the antibody-based therapy of cancer due to its higher expression in tumors relative to normal tissues. Great potential has been shown by anti-TfR antibodies combined with chemotherapeutic drugs as a
Mei-Yu Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 597-604 (2013-05-30)
To observe the analgesic effect of sinomenine on the neuropathic pain rat model induced by SSNI, and discuss its impact on monoamine neurotransmitters in striatal extracellular fluid. Male SD rats were randomly divided into the sham operation group, the SSNI
Y C Oh et al.
European review for medical and pharmacological sciences, 16(9), 1184-1191 (2012-10-11)
Sinomenine is an alkaloid compound and a prominent anti-inflammatory agent found in the root of the climbing plant Sinomenium acutum. However, its effects on the mechanism of human mast cell line (HMC)-1-mediated inflammation remained unknown. To provide insight into the
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