方案
97%
表单
solid
mp
190-193 °C (lit.)
SMILES字符串
CCOc1ccc2nc(sc2c1)S(N)(=O)=O
InChI
1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChI key
OUZWUKMCLIBBOG-UHFFFAOYSA-N
基因信息
human ... CA1(759) , CA12(771) , CA13(377677) , CA14(23632) , CA2(760) , CA3(761) , CA4(762) , CA5A(763) , CA5B(11238) , CA6(765) , CA7(766) , CA9(768)
mouse ... Car5a(12352)
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一般描述
6-乙氧基-2-苯并噻唑磺酰胺是一种膜渗透性碳酸酐酶抑制剂，已在正常白兔中对其眼部分布和药理学进行了研究。在体外引起抑制胰岛素降解 。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Gaspar Peña-Münzenmayer et al.
Pflugers Archiv : European journal of physiology, 466(7), 1317-1327 (2013-10-02)
TASK-2 is a K2P K(+) channel considered as a candidate to mediate CO2 sensing in central chemosensory neurons in mouse. Neuroepithelial cells in zebrafish gills sense CO2 levels through an unidentified K2P K(+) channel. We have now obtained zfTASK-2 from
Andreza Ribeiro et al.
Journal of the Royal Society, Interface, 9(74), 2059-2069 (2012-04-12)
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904)
Larissa A Shimoda et al.
American journal of physiology. Lung cellular and molecular physiology, 292(4), L1002-L1012 (2007-01-09)
Hypoxic pulmonary vasoconstriction (HPV) occurs with ascent to high altitude and can contribute to development of high altitude pulmonary edema (HAPE). Vascular smooth muscle contains carbonic anhydrase (CA), and acetazolamide (AZ), a CA inhibitor, blunts HPV and might be useful
Matthias C Jecklin et al.
Journal of molecular recognition : JMR, 22(4), 319-329 (2009-04-18)
We performed a systematic comparison of three label-free methods for quantitative assessment of binding strengths of proteins interacting with small molecule ligands. The performance of (1) nanoelectrospray ionization mass spectrometry (nESI-MS), (2) surface plasmon resonance (SPR), and (3) isothermal titration
T H Maren et al.
Experimental eye research, 55(1), 73-79 (1992-07-01)
We have measured sequentially the concentrations of ethoxzolamide (6-ethoxybenzothiazole-2-sulfonamide) in ocular tissues following its intravenous or topical administration to normal albino rabbits. This was done in parallel with determinations of intraocular pressure (IOP) measured by tonometer or direct manometry. Ethoxzolamide
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