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化驗
98%
SMILES 字串
Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13
InChI
1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
InChI 密鑰
VXPCQISYVPFYRK-UHFFFAOYSA-N
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生化／生理作用
爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。
Kamil Musilek et al.
Bioorganic & medicinal chemistry letters, 21(1), 150-154 (2010-12-15)
Carbamate inhibitors (e.g., pyridostimine bromide) are used as a pre-exposure treatment for the prevention of organophosphorus poisoning. They work by blocking acetylcholinesterase's (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. However, carbamate inhibitors are known
Kamil Musilek et al.
European journal of medicinal chemistry, 46(2), 811-818 (2011-01-18)
Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a positive charge in the molecule to ensure peripheral effect
Marketa Komloova et al.
Bioorganic & medicinal chemistry letters, 21(8), 2505-2509 (2011-03-15)
This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). Their inhibitory (IC(50)) and was compared to the chosen standards ambenonium dichloride, edrophonium chloride, BW284c51
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