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Merck
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文件

247898

Sigma-Aldrich

异山梨醇二甲醚

98%

别名:

DMI, 二甲基异山梨醇, 1,4:3,6-二脱水-2,5-二-O-甲基-D-葡糖醇, 1,4:3,6-二脱水山梨醇 2,5-二甲醚, 2,5-二-O-甲基-1,4:3,6-二脱水-D-葡糖醇, 异山梨醇二甲醚

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About This Item

经验公式（希尔记法）:
C8H14O4
CAS号:
5306-85-4
分子量:
174.19
Beilstein:
80854
EC號碼:
226-159-8
MDL號碼:
MFCD00064828
分類程式碼代碼:
12352005
PubChem物質ID:
24854898
NACRES:
NA.22

化驗

98%

形狀

liquid

光學活性

[α]21/D +96.1°, c = 2 in chloroform

折射率

n20/D 1.461 (lit.)

bp

93-95 °C/0.1 mmHg (lit.)

密度

1.15 g/mL at 25 °C (lit.)

SMILES 字串

CO[C@H]1COC2[C@@H](COC12)OC

InChI

1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1

InChI 密鑰

MEJYDZQQVZJMPP-ULAWRXDQSA-N

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應用

异山梨醇二甲醚（DMI）是一种可持续溶剂，广泛用于各种化妆品和药物配方中。
通用应用：
  • DMI 可用作环辛烯环氧化的替代绿色溶剂，异麦芽酮糖衍生醛与 α,β-不饱和酮的贝里斯－希尔曼反应，也可用于固相合成。
  • 它可以用作水性涂料的聚结剂，在失水阶段充当共溶剂，在成膜过程中充当聚结剂。

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

240.8 °F - closed cup

閃點（°C）

116 °C - closed cup

個人防護裝備

Eyeshields, Gloves

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Y Zhang et al.
International journal of cosmetic science, 41(5), 479-488 (2019-08-06)
Phenylethyl resorcinol (PR) has been used widely in the personal care industry as a novel skin lightening ingredient. Surprisingly, there is only limited information describing the physicochemical properties of this active. Therefore, the primary objective of this study was to
M Brisaert et al.
Pharmacy world & science : PWS, 18(5), 182-186 (1996-10-01)
Erythromycin, an antibiotic commonly used topically in the treatment of acne, is unstable in solution. The stability is influenced by the pH and by the presence of water. The influence of the pH on the stability of erythromycin was investigated
H Zia et al.
Pharmaceutical research, 8(4), 502-504 (1991-04-01)
Dimethyl isosorbide (DMI), which is currently under investigation for its potential use as a pharmaceutical vehicle and drug permeation enhancer, is a water-miscible liquid with relatively low viscosity. The solubilization behavior of DMI as a cosolvent for nonpolar drugs was
B W Barry et al.
The Journal of investigative dermatology, 82(1), 49-52 (1984-01-01)
The occluded vasoconstrictor assay was used to assess the effect of penetration enhancers on the topical bioavailability of a representative steroid, betamethasone 17-benzoate, with dimethylisosorbide (DMI) as a reference solvent. In the initial test, only N-methyl-2-pyrrolidone (NMP) increased the steroid
Isosorbide mono-and di-alkyl ethers, a new class of sustainable coalescents for water-borne paints.
Durand M, et al.
Progress in Organic Coatings, 69(4), 344-351 (2010)
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