所有图片(1)
About This Item
经验公式（希尔记法）:
C12H16N2O2
CAS号:
分子量:
220.27
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
推荐产品
化驗
97%
bp
147-149 °C/2 mmHg (lit.)
mp
36-40 °C (lit.)
SMILES 字串
C1CN(CCN1)Cc2ccc3OCOc3c2
InChI
1S/C12H16N2O2/c1-2-11-12(16-9-15-11)7-10(1)8-14-5-3-13-4-6-14/h1-2,7,13H,3-6,8-9H2
InChI 密鑰
NBOOZXVYXHATOW-UHFFFAOYSA-N
一般說明
The effect of 1-piperonylpiperazine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity was studied.
應用
1-Piperonylpiperazine was used in the synthesis of acetyl-caffeic acid-1-piperonylpiperazine (HBU-47).
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
235.4 °F - closed cup
閃點（°C）
113 °C - closed cup
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
K Hashimoto et al.
European journal of pharmacology, 228(2-3), 171-174 (1992-09-01)
The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated
Seon-Young Park et al.
International immunopharmacology, 19(1), 60-65 (2013-12-24)
In the present study, we synthesized a new hybrid compound by coupling caffeic acid and 1-piperonylpiperazine. The synthetic compound, acetyl-caffeic acid-1-piperonylpiperazine (HBU-47), showed potent anti-inflammatory effects inhibiting lipopolysaccharide (LPS)-induced production of nitric oxide (NO) in RAW264.7 macrophage cells. HBU-47 inhibited
Lilian H J Richter et al.
Journal of pharmaceutical and biomedical analysis, 143, 32-42 (2017-06-12)
Metabolism studies play an important role in clinical and forensic toxicology. Because of potential species differences in metabolism, human samples are best suitable for elucidating metabolism. However, in the case of new psychoactive substances (NPS), human samples of controlled studies
K Hashimoto et al.
Brain research, 590(1-2), 341-344 (1992-09-11)
The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [3H]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these
Marcelo Dutra Arbo et al.
Archives of toxicology, 90(12), 3045-3060 (2016-01-29)
The piperazine derivatives most frequently consumed for recreational purposes are 1-benzylpiperazine, 1-(3,4-methylenedioxybenzyl) piperazine, 1-(3-trifluoromethylphenyl) piperazine and 1-(4-methoxyphenyl) piperazine. Generally, they are consumed as capsules, tablets or pills but also in powder or liquid forms. Currently, the precise mechanism by which
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