推荐产品
化驗
98%
反應適用性
reaction type: click chemistry
bp
123-124 °C (lit.)
密度
1.427 g/mL at 25 °C (lit.)
SMILES 字串
CS(F)(=O)=O
InChI
1S/CH3FO2S/c1-5(2,3)4/h1H3
InChI 密鑰
KNWQLFOXPQZGPX-UHFFFAOYSA-N
一般說明
Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral - Skin Corr. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
D H Malin et al.
Neurobiology of aging, 14(4), 393-395 (1993-07-01)
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly
A W Snow et al.
Chemical research in toxicology, 1(6), 379-384 (1988-11-01)
The chemical reactivity and physical properties of methanesulfonyl fluoride (MSF) were quantitatively measured for direct comparison with those of isopropyl methylphosphonofluoridate (GB, sarin) and diisopropyl phosphorofluoridate (DFP). The chemistry involved reaction rate constant measurements of MSF hydrolysis and for reactions
L A Rodriguez et al.
Pharmacology, biochemistry, and behavior, 25(6), 1217-1221 (1986-12-01)
Perioral behaviors induced by neuroleptic drugs have been interpreted as an animal model of tardive dyskinesia. However, these behaviors have also been induced or enhanced by physostigmine, a cholinesterase inhibitor. The latter result is contradictory to the clinical effect of
Donald E Moss et al.
Journal of Alzheimer's disease : JAD, 55(3), 1285-1294 (2016-11-20)
Irreversible acetylcholinesterase (AChE) inhibition accumulates to high levels in the central nervous system (CNS) because AChE turnover in the brain is much slower than in peripheral tissues. As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF)
Weixuan Chen et al.
Biotechnology letters, 36(2), 337-340 (2013-10-09)
Fibrinogen is essential in the intrinsic and extrinsic blood coagulation process. Inhibition of fibrinogen aggregation could lead to anticoagulation effects. The availability of methods for easy quantitative evaluation of the coagulation process is critical to studying coagulation and its inhibition.
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