推荐产品
product name
罂粟碱 盐酸盐, powder
化驗
≥98%
形狀
powder
顏色
white
溶解度
H2O: 25 mg/mL
SMILES 字串
COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
InChI
1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChI 密鑰
UOTMYNBWXDUBNX-UHFFFAOYSA-N
基因資訊
human ... PDE4B(5142)
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一般說明
Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.
應用
Papaverine hydrochloride has been used:
- in oxygenated Krebs solution for tissue mechanics analysis
- as a vasodilator in heparinized horse serum in tissue uptake technique
- as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat
生化/生理作用
Papaverine is originally used to resolve male impotence.
Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.
特點和優勢
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
Increased glomerular albumin permeability in old spontaneously hypertensive rats
Nephrology, Dialysis, and Transplantation, 19(7), 1724-1731 (2004)
Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage
Neurocritical Care, 2(2), 124-132 (2005)
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice
The American Journal of Pathology, 179(3), 1549-1559 (2011)
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells
British Journal of Pharmacology, 137(6), 910-918 (2002)
Neuroradiology, 39(2), 90-98 (1997-02-01)
Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty. Our knowledge concerning the mechanism of action, method of administration and potential side effects of this therapeutic alternative are reviewed.
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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