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BACE1

beta-site APP-cleaving enzyme 1

别名:

ASP2, BACE, HSPC104

物种:

Human BACE1 (23621), Mouse Bace1 (23821), Rat Bace1 (29392), Horse BACE1 (100071137), naked mole-rat Bace1 (101701890), sheep BACE1 (101119667), dog BACE1 (489390), cow BACE1 (614333), chicken BACE1 (419768), Zebrafish bace1 (403005) ...展开

UniProtKB ID:

P56817, A0M8W7, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1

基因ID:

Human(23621) Summary: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Mouse(23821) beta-site APP cleaving enzyme 1
Rat(29392) beta-site APP cleaving enzyme 1
Horse(100071137) beta-site APP-cleaving enzyme 1
naked mole-rat(101701890) beta-site APP-cleaving enzyme 1
sheep(101119667) beta-site APP-cleaving enzyme 1
dog(489390) beta-site APP-cleaving enzyme 1
cow(614333) beta-site APP-cleaving enzyme 1
chicken(419768) beta-site APP-cleaving enzyme 1
Zebrafish(403005) beta-site APP-cleaving enzyme 1
domestic cat(101086840) beta-site APP-cleaving enzyme 1
domestic guinea pig(100135485) beta-site APP cleaving enzyme 1
Domestic Rabbit(100343442) beta-site APP-cleaving enzyme 1

产品 (20)
同行评审论文 (971)

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ELISA

货号

说明

物种

人BACE1 /β-分泌酶1 ELISA试剂盒, ,

物种

human

Activity Assay

货号

说明

物种

β-分泌酶(BACE1) 活性检测试剂盒（荧光法）, 1 kit sufficient for 250 reactions,

物种

human

Antibodies

货号

说明

物种反应性

应用

Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,

物种反应性

human

应用

western blot

抗-BACE1 兔抗, affinity isolated antibody,

物种反应性

bovine, dog, guinea pig, horse, human, mouse, rabbit, rat

应用

immunofluorescence
immunohistochemistry
western blot

抗-BACE抗体，CT，克隆61-3E7, clone 61-3E7, Chemicon^®, from mouse,

物种反应性

human, mouse, primate, rat

应用

immunoprecipitation (IP)
western blot

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,

物种反应性

human

应用

microarray
western blot

Anti-BACE Antibody, CT, Chemicon^®, from rabbit,

物种反应性

human

应用

immunohistochemistry
western blot

Small Molecule - Inhibitor

货号

说明

物种

(−)-儿茶素没食子酯酸, ≥98% (HPLC), from green tea,

物种

human

(-)-儿茶素, ≥97% (HPLC), from green tea,

物种

human

(−)-表儿茶素, ≥90% (HPLC),

物种

human

(−)-表儿茶素, ≥98% (HPLC), from green tea,

物种

human

Kits

货号

说明

物种

β-分泌酶(BACE1) 活性检测试剂盒（荧光法）, 1 kit sufficient for 250 reactions,

物种

human

Proteins

货号

说明

物种

β-分泌酶人, recombinant, expressed in HEK 293 cells (C-terminal FLAG tagged), extracellular domain, ≥10,000 units/mg protein, ≥90% (SDS-PAGE), buffered aqueous solution,

物种

human

esiRNA

货号

说明

物种

MISSION^® esiRNA, targeting human BACE1,

物种

human

MISSION^® esiRNA, targeting mouse Bace1,

物种

mouse