mAbs Characterization & Quality Control
The key for ensuring drug safety and efficacy
Characterization and quality control of monoclonal antibodies (mAbs) is essential to ensure their efficacy and safety. Analytical techniques, like HPLC and mass spectrometry, are vital to assess various properties, such as aggregation, charge variants, and post-translational modifications (PTMs). Our extensive selection of products supports the detailed analysis and evaluation of mAbs to maintain quality and effectiveness.
Peptide Mapping of Monoclonal Antibodies
We offer a broad range of high-quality products that are essential for your peptide mapping and critical quality attribute evaluation throughout the monoclonal antibody workflow.
Peptide mapping requires high-efficiency reversed-phase chromatography (RPC) columns to ensure high sequence coverage. We offer a selection of wide-pore, RPC columns designed for peptide mapping.
We offer standards and certified reference materials for mAbs, intact proteins, peptides, amino acids, including SILu™Mab Stable-Isotope Labeled Universal Monoclonal Antibody, for mass spectrometry testing applications.
We offer a broad portfolio of proteases, cleavage agents, and digestion buffers & kits to facilitate protein digestion.
- Low-Artifact Digestion Buffer is optimized for digestion of therapeutic proteins and antibodies prior to peptide mapping by LC-UV-MS.
- Recombinant Trypsin hydrolyzes peptide bonds specifically at the carboxyl side of arginine and lysine residues and is formulated for in-solution digestion or in-gel digestion and peptide mapping by mass spectrometry.
- Our SOLu-Trypsin Rapid Digestion Kit provides a fast and efficient method for protein digestion for proteomics.
- Lys-c (lysyl-endopeptidase) hydrolyzes amide bonds at the carboxylic side of lysine residues.
Related Categories
Discover our wide-pore, RPC columns specifically designed for peptide mapping.
Explore our standards and certified reference materials for mass spectrometry testing applications.
Streamline protein digestion to enable advanced analysis and characterization.
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Related Webinars
Learn how to enable and maintain high quality and high sensitivity in LC-MS analyses by preventing impurities and contaminations.
Explore a simple and high throughput method for the quantitation of monoclonal antibodies and proteins in human and animal serum.
Discover tips for bottom-up analysis of mAbs and the role of column chemistry in highly selective HPLC methods.
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