SML0016

CCG-63802

• Sinónimos: α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
• Fórmula empírica (notación de Hill): C₂₆H₁₈N₄O₂S
• Número de CAS: 620112-78-9
• Peso molecular: 450.51
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Nivel de calidad: 100
• Formulario: powder
• color: yellow
• solubilidad: DMSO: ≥5 mg/mL (;warmed DMSO)
• temp. de almacenamiento: room temp

Descripción

Aplicación

CCG-63802 may be used to study G-protein-mediated cell signaling.

Acciones bioquímicas o fisiológicas

CCG-63802 is a reversible, allosteric inhibitor of RGS4

GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable