S6317

L-Sulforaphane

≥95% (HPLC), oil

• Sinónimos: (R)-1-Isothiocyanato-4-(methylsulfinyl)butane, 4-Methylsulfinylbutyl isothiocyanate
• Fórmula empírica (notación de Hill): C₆H₁₁NOS₂
• Número de CAS: 142825-10-3
• Peso molecular: 177.29
• Número MDL: MFCD09039283
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724618
• NACRES: NA.77

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: oil
• actividad óptica: [α]/D -70 to -90°, c = 1.0 in chloroform-d
• color: light yellow
• solubilidad: DMSO: >5 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1
• Clave InChI: SUVMJBTUFCVSAD-SNVBAGLBSA-N

Descripción

Aplicación

L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes⁶ and murine macrophage RAW 264.7 cell line.⁷

Acciones bioquímicas o fisiológicas

L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.^3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.^3,5

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves