S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Sinónimos: 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Fórmula empírica (notación de Hill): C₆H₁₁NOS₂
• Número de CAS: 4478-93-7
• Peso molecular: 177.29
• Número MDL: MFCD00198068
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724610
• NACRES: NA.77

Propiedades

• Nombre del producto: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• origen biológico: synthetic
• Ensayo: ≥90% (HPLC)
• Formulario: liquid
• solubilidad: DMSO: soluble 40 mg/mL; H₂O: insoluble
• compatibilidad: for use with ABI 7500
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• Clave InChI: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Descripción

Aplicación

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Acciones bioquímicas o fisiológicas

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)