O4636

Oxytetracycline dihydrate

Assay (anhydrous basis) 95.0%-102.0%

• Sinónimos: 5-Hydroxytetracycline dihydrate, Oxytetracycline, Oxytetracycline Anhydrous
• Fórmula empírica (notación de Hill): C₂₂H₂₄N₂O₉ · 2H₂O
• Número de CAS: 6153-64-6
• Peso molecular: 496.46
• Número CE: 201-212-8
• Número MDL: MFCD00151234
• Código UNSPSC: 51284038
• ID de la sustancia en PubChem: 24898000
• NACRES: NA.85

Propiedades

• Nivel de calidad: 200
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria
• Modo de acción: protein synthesis | interferes
• cadena SMILES: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
• Clave InChI: IBZHEBHGZFICKS-IFLJXUKPSA-N

Descripción

Descripción general

Chemical structure: tetracycline

Aplicación

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

Acciones bioquímicas o fisiológicas

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Nota de análisis

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

Otras notas

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

Información de seguridad

• Pictogramas: GHS08,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H361d,H411
• Consejos de prudencia: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Clasificaciones de peligro: Aquatic Chronic 2 - Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)