L5385
α-Lactalbumin from bovine milk
Type I, ≥85% (PAGE), lyophilized powder
Sinónimos:
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
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Productos recomendados
origen biológico
bovine milk
Nivel de calidad
tpo
Type I
Ensayo
≥85% (PAGE)
Formulario
lyophilized powder
concentración
≥85 % protein
técnicas
cell culture | mammalian: suitable
electrophoresis: suitable
impurezas
calcium, tested
solubilidad
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
cow ... LALBA(281894)
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Descripción general
α-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.[1]
Aplicación
Acciones bioquímicas o fisiológicas
α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form.[5] α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex. [6][7] The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Α° resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.[1]
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.
Calidad
Calcium saturated. May have traces of ammonium sulfate and sodium phosphate
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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