I4657
Insulin-like Growth Factor-I Receptor human
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Sinónimos:
IGF-I Receptor
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About This Item
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in NSO cells
Ensayo
≥95% (SDS-PAGE)
Formulario
lyophilized powder
mol peso
α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa
envase
pkg of 50 μg
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IGF1R(3480)
Descripción general
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
Aplicación
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
Acciones bioquímicas o fisiológicas
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
Forma física
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
Nota de análisis
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Xin Huang et al.
PloS one, 10(7), e0133152-e0133152 (2015-07-15)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R)
Sandra Heskamp et al.
PloS one, 10(2), e0117745-e0117745 (2015-02-14)
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy and to study
Jin-Ho Choi et al.
The Journal of clinical endocrinology and metabolism, 96(1), E130-E134 (2010-10-22)
Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and
Robert Root-Bernstein et al.
Frontiers in endocrinology, 5, 118-118 (2014-08-08)
Insulin (INS) resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome, and obesity. The mechanism by which INS and estrogen interact is unknown. We hypothesize that estrogen binds directly to
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