Saltar al contenido
Merck
Todas las fotos(1)

Documentos

H6904

Sigma-Aldrich

6β-Hydroxycortisol

≥98%

Sinónimos:

4-Pregnene-6,11β,17,21-tetrol-3,20-dione

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C21H30O6
Número de CAS:
3078-34-0
Peso molecular:
378.46
MDL number:
MFCD00200405
UNSPSC Code:
51111800
PubChem Substance ID:
24895777
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98%

form

powder

technique(s)

HPLC: suitable

solubility

methanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CC12CCC(=O)C=C1C(O)CC3C4CC[C@](O)(C(=O)CO)C4(C)CC(O)C23

InChI

1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12?,13?,15?,16?,18?,19?,20?,21-/m0/s1

InChI key

GNFTWPCIRXSCQF-JFQOUMBGSA-N

Application

6β-Hydroxycortisol has been used in liquid chromatography with tandem mass spectrometry (LC/MS/MS) analysis to confirm the human embryonic kidney (HEK293) cell-based conversion of parent cortisol to 6β-hydroxycortisol (6βOH) metabolites.

Biochem/physiol Actions

6β-Hydroxycortisol serves as a substrate for the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins (MATE1 and MATE-2K).
6β-Hydroxycortisol is a metabolite of cortisol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Yuichiro Imamura et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(4), 685-694 (2014-02-04)
6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3 and MATEs to the
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico