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The stability of this product in solution has not been evaluated. Generally, peptides should not be stored in solution for extended periods. Should solution storage be necessary, storing aliquots at -20°C is suggested. Note that peptides have a tendency to stick to plastic containers upon storage.
G9145
[Leu15]-Gastrin I human
≥95% (HPLC)
Sinónimos:
[Leu15]-HG-17, LHG-17, [15-Leucine]-Gastrin I, human heptadecapeptide, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human, [Leu15]-Gastrin I, human, [Leucine15]-Gastrin I heptadecapeptide, [Leucine15]-Little gastrin I
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About This Item
Fórmula empírica (notación de Hill):
C98H126N20O31
Número de CAS:
Peso molecular:
2080.16
Beilstein:
5227423
Número CE:
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
human
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
powder
técnicas
cell culture | mammalian: suitable
Nº de acceso UniProt
temp. de almacenamiento
−20°C
cadena SMILES
CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O
InChI
1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)
Clave InChI
CMVMLPDUAGUTOC-UHFFFAOYSA-N
Información sobre el gen
human ... GAST(2520)
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Amino Acid Sequence
Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
Descripción general
GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2.[1] G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin.[1] Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR).[2] Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.[1]
Aplicación
Acciones bioquímicas o fisiológicas
Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.
Otras notas
Lyophilized from 0.1% TFA in H2O
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
D Chen et al.
Scandinavian journal of gastroenterology, 31(4), 404-410 (1996-04-01)
Gastrin is thought to stimulate growth of the pancreas via gastrin/cholecystokinin (CCK)-B-type receptors. The aim of the present study was to examine the trophic response of the pancreas to exogenous gastrin or to hypergastrinemia of endogenous origin and to hypogastrinemia
Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy
Mahe MM, et al.
Journal of Visualized Experiments, (97), e52483-e52483 (2015)
C M Zhao et al.
Cell and tissue research, 291(2), 315-323 (1998-03-28)
Ageing cells, especially post-mitotic cells, are known to accumulate pigments, i.e. highly electron-dense material, referred to as ceroid or lipofuscin. This material is formed as a consequence of autophagocytosis and peroxidation of the products undergoing degradation. The present study describes
Handbook of Biologically Active Peptides, 1219-1226 (2013)
Gastrin and gastric cancer
Smith JP, et al.
Cellular and molecular gastroenterology and hepatology, 4(1), 75-83 (2017)
Artículos
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
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After preparing aliquots, what is the stability of this product at -20?
1 answer-
Helpful?
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Is this product also suitable for use with other mammalian species, such as mouse, for ex vivo tissue studies, as opposed to just human organoid culture medium?
1 answer-
The product's validation for batch release does not currently cover murine ex vivo tissue testing. However, the following citations may provide insights into its application for ex vivo non-human samples:
Sci Adv. 2023 Nov 17;9(46):eadh0322. Title: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells PMID: 37967175
Infect Immun. 2016 Sep 19;84(10):3083-91. Title: Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins PMID: 27481254
Helpful?
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I am interested in this product. A colleague uses it for human organoid culture medium. However, I work with murine ex vivo tissues. Is this also applicable for other mammalian species (so mouse in stead of human)?
1 answer-
This product has not been tested for use with murine ex vivo tissue. However, the following citations may be of interest for its application in ex vivo non-human samples.
Sci Adv. 2023 Nov 17;9(46):eadh0322.
Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells
PMID: 37967175
https://pubmed.ncbi.nlm.nih.gov/37967175/Infect Immun. 2016 Sep 19;84(10):3083-91.
Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins
PMID: 27481254
https://pubmed.ncbi.nlm.nih.gov/27481254/Helpful?
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この製品の溶媒は何を用いればよろしいでしょうか。水またはPBS(-)には溶けますでしょうか、あるいはDMSOでしょうか。
1 answer-
This product is tested for solubility at 1mg/ml in 0.1% NaOH or 1% NH4OH. Other solvents have not been evaluated.
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