D7006

Dihydrofolic acid

≥90%

• Sinónimos: 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH₂
• Fórmula empírica (notación de Hill): C₁₉H₂₁N₇O₆
• Número de CAS: 4033-27-6
• Peso molecular: 443.41
• Beilstein: 69017
• Número MDL: MFCD00083619
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 24894068
• NACRES: NA.79

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥90%
• Formulario: powder
• color: light yellow to dark yellow-orange
• temp. de almacenamiento: −20°C
• cadena SMILES: NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
• InChI: 1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
• Clave InChI: OZRNSSUDZOLUSN-LBPRGKRZSA-N
• Información sobre el gen: human ... DHFRP1(573971) ; mouse ... Dhfr(13361)

Descripción

Descripción general

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Aplicación

Dihydrofolic acid has been used in diaphorase-coupled assay for dihydrofolate reductase (DHFR) activity. It has also been used as a component in assay buffer to determine dihydrofolate reductase (DHFR) activity.

Acciones bioquímicas o fisiológicas

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Envase

Sealed ampule.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves