F7876

Folic acid

≥97%

• Sinónimos: PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Fórmula empírica (notación de Hill): C₁₉H₁₉N₇O₆
• Número de CAS: 59-30-3
• Peso molecular: 441.40
• Beilstein/REAXYS Number: 100781
• EC Number: 200-419-0
• MDL number: MFCD00079305
• UNSPSC Code: 12352106
• eCl@ss: 34058014
• PubChem Substance ID: 57654192
• NACRES: NA.79

Propiedades

• biological source: synthetic (organic)
• assay: ≥97%
• form: powder
• technique(s): HPLC: suitable
• color: faint orange to dark orange-yellow; faint yellow to dark yellow
• mp: >285 °C
• storage temp.: room temp
• SMILES string: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• InChI key: OVBPIULPVIDEAO-LBPRGKRZSA-N

Descripción

Application

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Biochem/physiol Actions

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)