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50359

Sigma-Aldrich

Voglibose

≥97.0% (TLC)

Sinónimos:

3,4-Dideoxy-4-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-D-epi-inositol, N-(1,3-Dihydroxyprop-2-yl)valiolamine

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About This Item

Fórmula empírica (notación de Hill):
C10H21NO7
Número de CAS:
83480-29-9
Peso molecular:
267.28
MDL number:
MFCD00865496
UNSPSC Code:
12352201
PubChem Substance ID:
329757591
NACRES:
NA.25

biological source

synthetic

assay

≥97.0% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1

InChI key

FZNCGRZWXLXZSZ-CIQUZCHMSA-N

Gene Information

human ... GAA(2548) , MGAM(8972) , MGAM2(93432) , SI(6476)

Application

Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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E Araki et al.
Diabetes, obesity & metabolism, 15(4), 364-371 (2012-11-21)
In a phase III study conducted among Japanese patients with type 2 diabetes mellitus (T2DM), linagliptin 5 and 10 mg showed clinically meaningful improvements in glycaemic parameters after 12 and 26 weeks compared with placebo and voglibose, respectively. This extension study assessed
R M Coleman et al.
Journal of analytical toxicology, 42(7), e61-e64 (2018-05-26)
A case of an elderly female with suspected paralytic shellfish poisoning (PSP) is presented. The patient shared a meal of recreationally-harvested shellfish with her family and soon began to experience nausea and weakness. She was taken to the local emergency
Junichi Kato et al.
International journal of molecular sciences, 21(6) (2020-03-27)
Type 2 diabetes mellitus and its related insulin resistance are known to increase the risk of cancer. Anti-diabetic agents can improve insulin resistance and may lead to the suppression of carcinogenesis. This study aimed to investigate the preventive effects of
Xiaolong Chen et al.
Current medicinal chemistry, 13(1), 109-116 (2006-02-07)
The number of people with diabetes is expected to rise from the current estimated 150 million to 220 million in 2010 and 300 million in 2025, and 90% is Type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM). Voglibose, one
Devasier Bennet et al.
International journal of nanomedicine, 7, 3399-3419 (2012-08-14)
Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactideco-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of
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