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M9017

Supelco

Mepirizole

analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C11H14N4O2
Número de CAS:
18694-40-1
Peso molecular:
234.25
EC Number:
242-507-1
MDL number:
MFCD00057351
UNSPSC Code:
41116107
PubChem Substance ID:
329818077
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC1=NC(N2C(OC)=CC(C)=N2)=NC(OC)=C1

InChI

1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3

InChI key

RHAXSHUQNIEUEY-UHFFFAOYSA-N

General description

Mepirizole belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs), widely used in the treatment of pain and inflammation.

Application

Mepirizole may be used as an analytical reference standard for the quantification of the analyte in animal samples using ultra-high-performance liquid chromatography with tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
066H0190
012H0713

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K Takeuchi et al.
Alimentary pharmacology & therapeutics, 13(1), 87-96 (1999-01-20)
S-0509, 2-[(tert-butoxycarbonylmethyl) [(m-(carboxy-phenyl)-ureidomethyl-carbonyl]] aminobenzo phenone, was developed as a potent and selective CCKB/gastrin receptor antagonist that does not affect the central nervous system. We evaluated the effects of S-0509 on gastric acid secretion and duodenal ulcerogenic and healing responses in
M Ikeda et al.
Chemical & pharmaceutical bulletin, 44(9), 1700-1706 (1996-09-01)
(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1-yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
F Iwata et al.
Digestive diseases and sciences, 40(5), 1112-1117 (1995-05-01)
The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine (IAP) autoradiography
D Renzi et al.
Advances in experimental medicine and biology, 298, 129-135 (1991-01-01)
We have investigated the endogenous levels of duodenal calcitonin gene-related peptide- (CGRP) and Substance P- (SP) like immunoreactivity (li) following the induction of duodenal ulcers in rats. Using three duodenal ulcerogens, namely cysteamine, dulcerozine or mepirizole given in a single
S Evangelista et al.
Neuroscience letters, 112(2-3), 352-355 (1990-05-04)
Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with
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