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F6377

Sigma-Aldrich

Fluorescein sodium salt

Fluorescein sodium salt

Powder

Sinónimos:

Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine

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About This Item

Fórmula empírica (notación de Hill):
C20H10Na2O5
Número de CAS:
518-47-8
Peso molecular:
376.27
Colour Index Number:
45350
Beilstein/REAXYS Number:
3833041
EC Number:
208-253-0
MDL number:
MFCD00167039
UNSPSC Code:
12171500
PubChem Substance ID:
24894907
NACRES:
NA.47
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Nombre del producto

Fluorescein sodium salt, used as fluorescent tracer

Quality Level

200

form

powder

technique(s)

titration: suitable

color

orange to brown

pH

8.3 (20 °C, 10 g/L)

mp

>300 °C

solubility

H2O: 1 mg/mL

density

0.78 g/cm3 at 29.6 °C (85.3 °F at 699.7 hPa)

fluorescence

λex 460 nm; λem 515 nm(lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2

InChI key

RGPLGPBQJOQFJS-UHFFFAOYSA-L

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General description

Fluorescein is a xanthene dye and is a common labeling agent in biology.[1]

Application

Fluorescein sodium salt has been used as a solute to study microvessel permeability.[2][3] It has been used as a test molecule to study blood barrier penetration.[4]
Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius.[5] Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models.[6][7][8] The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes.[9] Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).[10]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

423.7 °F - Pensky-Martens closed cup

flash_point_c

217.6 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SHBS2708
SHBS3018
0000240645
0000150889
0000182362

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Advanced Fluorescence Reporters in Chemistry and Biology I: Fundamentals and Molecular Design (2010)
The acute and chronic toxicity of two xanthene dyes, fluorescein sodium salt and phloxine B, to Daphnia pulex.
Walthall WK and Stark JD.
Environmental Pollution (Barking, Essex : 1987), 104(2), 207-215 (1999)
Dimitris N Xanthos et al.
Molecular pain, 8, 44-44 (2012-06-21)
Changes in the blood-central nervous system barriers occur under pathological conditions including inflammation and contribute to central manifestations of various diseases. After short-lasting peripheral and neurogenic inflammation, the evidence is mixed whether there are consistent blood-spinal cord changes. In the
Vascular endothelial growth factor enhances cancer cell adhesion to microvascular endothelium in vivo.
Shen S
Experimental Physiology, 95, 369-369 (2010)
Structural mechanisms of acute VEGF effect on microvessel permeability.
American Journal of Physiology. Heart and Circulatory Physiology, 284, H2124-H2124 (2003)
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Questions

1–4 of 4 Questions  

  1. What is the purity of Fluorescein sodium salt (CAS number 518-47-8, article number F6377-100G)?

    1 answer

    1. This purity of this product is not determined.

      Helpful?

  2. Can this product be autoclaved once dissolved? How long can a concentrated dissolved stock solution be stored for?

    1 answer

    1. The stability of Fluorescein under autoclave conditions has not been determined. Solutions have typically been filter sterilized. Long term solution stability has also not been evaluated. However, solutions of Fluorescein Diacetate are stable at -20°C in ethanol when protected from light. Similar stability would be expected with the sodium salt form.

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  3. Hello, I am interested in Fluorescein or Fluoresein sodium salt to perform angiography in the living mouse and would like to know if your product has a pharmacological grade. Which product is used for angiography?

    1 answer

    1. Unfortunately, a pharmacological grade Fluorescein or Fluorescein sodium salt is not available at this time.

      Helpful?

  4. Is F6377 soluble in ethanol?

    1 answer

    1. The substance is soluble in water (500 g/l) at 20°C and slightly soluble in ethanol, but insoluble in benzene, chloroform, and ether.

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