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Key Documents

MAB4306

Sigma-Aldrich

Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

clone 4F7.2, Chemicon®, from mouse

Sinónimos:

hLIF

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4F7.2, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

input

sample type neural stem cell(s)
sample type hematopoietic stem cell(s)

isotype

IgG1

NCBI accession no.

NM_002309.2

UniProt accession no.

P15018

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... LIF(3976)

Categorías relacionadas

General description

Leukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.

Application

Detect Human Leukemia Inhibitory Factor using this Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 validated for use in ELISA & WB.
Research Category
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation

Physical form

Format: Purified

Analysis Note

Control
Jurkat whole cell lysate

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Syed Azmal Ali et al.
PloS one, 13(6), e0198523-e0198523 (2018-06-14)
Leukemia Inhibitory Factor (LIF) is a polyfunctional cytokine, involved in numerous regulatory effects in vivo and in vitro, varying from cell proliferation to differentiation, and has therapeutic potential for treating various diseases. In the current study, a COS-1 cell line
Martin Mueller et al.
Stem cells and development, 26(4), 239-248 (2016-11-16)
The development of a mammalian brain is a complex and long-lasting process. Not surprisingly, preterm birth is the leading cause of death in newborns and children. Advances in perinatal care reduced mortality, but morbidity still represents a major burden. New
Weiwei Xue et al.
iScience, 26(1), 105898-105898 (2023-01-18)
The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human spinal cord tissue in vitro is challenging. Here, we demonstrated a novel method for generation of human dorsoventral spinal cord organoids

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