Saltar al contenido
Merck
Todas las fotos(1)

Documentos

613560

Sigma-Aldrich

TMPyP4

≥90% (TLC), solid, telomerase inhibitor, Calbiochem®

Sinónimos:

TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C44H38N8 · C28H28O12S4
Número de CAS:
36951-72-1
Peso molecular:
1363.60
MDL number:
MFCD00013468
UNSPSC Code:
12352200
NACRES:
NA.77

product name

TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

Quality Level

100

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

purple

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3

InChI key

AKZFRMNXBLFDNN-UHFFFAOYSA-K

General description

A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.
A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 6.5 µM inhibiting human telomerase

Warning

Toxicity: Standard Handling (A)

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Sreejana Ray et al.
ACS chemical biology, 15(4), 925-935 (2020-03-29)
Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA-binding specificity. Here, we use custom DNA microarrays to examine the
Hannah O Ajoge et al.
Viruses, 14(11) (2022-11-25)
The integration of the HIV-1 genome into the host genome is an essential step in the life cycle of the virus and it plays a critical role in the expression, long-term persistence, and reactivation of HIV expression. To better understand
Kohji Mori et al.
The Journal of biological chemistry, 297(4), 101120-101120 (2021-08-28)
GGGGCC (G4C2) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide repeat proteins produced through repeat-associated non-AUG (RAN) translation are recognized as potential drivers for neurodegeneration. Therefore, selective inhibition of
Ying Yang et al.
PLoS genetics, 17(10), e1009834-e1009834 (2021-10-14)
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the
Geng Liu et al.
Nature communications, 13(1), 1444-1444 (2022-03-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules, as well as the virus per se
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico