Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

474788

Sigma-Aldrich

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®

Sinónimos:

InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C26H41N3O5
Peso molecular:
475.62
Código UNSPSC:
12352200
NACRES:
NA.77

Nombre del producto

MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor

Nivel de calidad

100

Ensayo

≥95% (HPLC)

Formulario

liquid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

Condiciones de envío

ambient

temp. de almacenamiento

−70°C

Descripción general

Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Ki = 4 nM for proteasomal inhibition
Reversible: yes
Secondary Target
IKK

Envase

Packaged under inert gas

Advertencia

Toxicity: Flammable (J)

Reconstitución

Following initital thaw, aliquot and freeze (-70°C).

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palabra de señalización

Danger

Frases de peligro

H225,H319

Clasificaciones de peligro

Eye Irrit. 2 - Flam. Liq. 2

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

53.6 °F - closed cup - Information refers to the main ingredient.

Punto de inflamabilidad (°C)

12 °C - closed cup - Information refers to the main ingredient.

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Mitchell H Omar et al.
The Biochemical journal, 480(12), 875-890 (2023-06-12)
Cushing's syndrome is an endocrine disorder caused by excess production of the stress hormone cortisol. Precision medicine strategies have identified single allele mutations within the PRKACA gene that drive adrenal Cushing's syndrome. These mutations promote perturbations in the catalytic core
Chitra Rawat et al.
Cancer research, 83(24), 4142-4160 (2023-10-06)
Prostate cancer remains the second leading cause of cancer death in men in Western cultures. A deeper understanding of the mechanisms by which prostate cancer cells divide to support tumor growth could help devise strategies to overcome treatment resistance and

Contenido relacionado

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico