1.37162

D-Manitol

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Sinónimos: manitol
• Fórmula empírica (notación de Hill): C₆H₁₄O₆
• Número de CAS: 69-65-8
• Peso molecular: 182.17
• Beilstein/REAXYS Number: 1721898
• MDL number: MFCD00064287
• UNSPSC Code: 12352201

Propiedades

• agency: BP; ChP; JP; Ph. Eur.; USP
• Quality Level: 500
• product line: EMPROVE^® EXPERT
• form: solid
• impurities: low in endotoxins
• pH: 5.0-6.5 (120 °C, 182 g/L)
• bp: 290-295 °C/4.67 hPa
• mp: 166-169 °C; 167-170 °C (lit.)
• solubility: 213 g/L
• application(s): liquid formulation; ophthalmics; parenterals; pharma/biopharma processes
• storage temp.: 2-25°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
• InChI key: FBPFZTCFMRRESA-KVTDHHQDSA-N

Descripción

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Mannitol is a sugar alcohol which is used widely in biomolecule formulations as a stabilizer, bulking agent, and lyoprotecting agent, especially in lyophilization. Due to its low microbial and endotoxin limits, D(-)-Mannitol Emprove^® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

Un alditol edulcorante. Utilizado en estudios de inhibición del dulzor.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable