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Key Documents

SML0594

Sigma-Aldrich

CGP 55845 hydrochloride

≥98% (HPLC)

Synonym(s):

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydro xypropyl](phenylmethyl)phosphinic acid hydrochloride, CGP 55845A, CGP55845

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About This Item

Empirical Formula (Hill Notation):
C18H22Cl2NO3P · HCl
CAS Number:
Molecular Weight:
438.71
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

InChI

1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

InChI key

ZODSPDOOCZZEIM-BBRMVZONSA-N

Biochem/physiol Actions

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ahmad A Khundakar et al.
European journal of pharmacology, 671(1-3), 33-38 (2011-09-21)
Brain-derived neurotrophic factor (BDNF) has been suggested as a target for antidepressant treatment and chronic antidepressant drug administration shows a 'biphasic effect' on BDNF mRNA in rat hippocampus (transient decrease followed by an increase). In comparison, following acute administration only
Mark O Cunningham et al.
Epilepsia, 53(7), 1205-1214 (2012-06-13)
We describe a form of very fast oscillation (VFO) in patient electrocorticography (ECoG) recordings, that can occur prior to ictal events, in which the frequency increases steadily from ≈ 30-40 to >120 Hz, over a period of seconds. We dub
Wendy W Wu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(7), 2638-2648 (2011-02-18)
Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are prevented with estrogen (E(2))-containing hormone replacement therapy initiated shortly following OVX but not after substantial delay. Currently, the cellular
Court A Hull et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(14), 5895-5902 (2013-04-05)
Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics
Michael H Myoga et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(14), 5235-5243 (2011-04-08)
R-type calcium channels in postsynaptic spines signal through functional calcium microdomains to regulate a calcium/calmodulin-sensitive potassium channel that in turn regulates postsynaptic hippocampal long-term potentiation (LTP). Here, we ask whether R-type calcium channels in presynaptic terminals also signal through calcium

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